The liver plays a key role in the metabolic homeostasis of the whole organism.To carry out its functions, it is endowed with a peculiar circulatory system, made of three main dendritic flow structures and lobules.Understanding the vascular anatomy of the liver is clinically relevant since various liver pathologies are related to vascular disorders.
Noncanonical usage of stop codons in ciliates expands proteins with structurally flexible Q-rich motifs
Serine(S)/threonine(T)-glutamine(Q) cluster domains (SCDs), polyglutamine (polyQ) tracts and polyglutamine/asparagine (polyQ/N) tracts are Q-rich motifs found in many proteins.SCDs often are intrinsically disordered regions that mediate protein phosphorylation Sweatshirts and protein-protein interactions.PolyQ and polyQ/N tracts are structurally fl